A direct comparison in mice demonstrated that sequential prime-boost vaccination with their three constructs (6 vaccinations in total) induced a stronger antibody response than simultaneous vaccination (prime and then boost with a mixture of all three, 2 vaccinations in total) [149]
Substantially larger published research base over 100 published studies spanning five decades
Changing in pH and salt concentration will alter electrostatic interactions between charged amino acids
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These findings have led to increased interest in evaluating the therapeutic potential of VEGF as a neuroprotective agent in neurodegenerative diseases (Storkebaum and Carmeliet 2004)